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Once CO binds to one of the four binding sites of hemoglobin, the hemoglobin is altered so greater tissue hypoxia is required before O 2 will be released from the other binding sites Hsia

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Studies have reported recognized SABs in approximately 12 percent of pregnancies, and most occur before 12 weeks of gestation Regan et al. However, this finding was modified by age: shorter follicular phases were associated with smoking only among women older than 35 years of age.

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